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Interviewer: So a devil's advocate would say, okay, if someone has a
clogged artery and they need a stent or a bypass what is in there that's,
that is the clog?
Jonny Bowden, PhD, CNS: A toxic waste dump. And yes, there is some of this
LDL-B stuff in there but there's a lot of other stuff as well.
Interviewer: Okay.
Dr. Bowden: The LDL doesn't even begin to cause a problem until there's
inflammation. See, inflammation is at the heart of heart disease. It's
really the cause. Without inflammation nothing gets stuck in there. What
inflammation does is there's these little minor injuries in the vascular
walls, these little pockets. In that different debris gets stuck. Those
little LDL-B particles being one of them, not the only one. Oxidation,
oxidative damage happens. It happens to the LDL-B particles. It happens to
other things. This oxidative damage creates more inflammation until you
have a whole inflammatory cascade with all these inflammatory cytokines
going to the site of the injury. It makes this kind of toxic dump,
attracting inflammatory cells until it becomes kind of a yellow, goozy mess
and that's your plaque.
None of this happens without inflammation and oxidation, so those should be
the target of heart disease prevention, not cholesterol. Blaming
cholesterol for this toxic mess is like blaming the fireman for the fire. I
mean, it shows up at the scene of the crime but it's not the perpetrator.
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Dr. Jonny Bowden, author of The Great Cholesterol Myth, describes the main causes of heart disease. He says cholesterol plays a small role, but it's not the main culprit in heart disease.
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