Interviewer: You mentioned stress earlier. What does magnesium do when it
comes to stress and sleep as well because I think those two can be tied
Dr. Guosong Liu: Yeah. So this actually... this part comes from a, what I
call, almost like an accident of our study. In our early study we are
intend to develop a memory enhancer. So we think we did it. So that paper
was published two years ago. But after that, we started to worry, memory,
you have good memory and a bad memory and the worse memory is fear memory.
Right? So if you fear something, and then, obviously, what if [inaudible
00:00:40] has memory where it has your fear memory. And then that would be
So that trigger us to do the second study to specifically look at whether
we enhance memory generically or whether we really also enhance fear
memory. Because when you talk about memory enhancer, how can you imagine
this memory enhancer only has good memory and not bad memory. So, we start
In fact, in my opinion, for a lot of people, they remember bad stuff better
than good stuff. Well, that should be because bad stuff can hurt you.
Right? Good stuff just make your life better. Bad stuff can kill you.
Right? If you don't recognize the fire is going to kill you. Right?
So then we started to look at bad memory and then we have found it's
interesting [inaudible 00:01:29] brain magnesium do not enhance, doesn't
touch the bad memory, the fear memory circuitry. There's a specific
circuitry to store those fear memories and fear memories are not in
[inaudible 00:01:40] magnesium. But it's more interesting is that we bring
up, you know, in the human or, in fact, you know, very advanced, like a
mammal, has a way to suppress the bad memory. The brain region which
controls this [inaudible 00:01:58] suppress our bad memory. You know,
suppress our fear. And that brain region is enhanced by magnesium. So,
therefore, when we increase the brain magnesium, not only we don't enhance
fear memory, we enhance control of fear memory. So that work was published
Now, finally, we bring this... how that's important to the stress because
after the stress is you feel you are unable to control the fear. You worry,
lost job, you worry you're kids cannot go to Harvard or to Ivy League
school or you worry, whatever you worry. You worry your grass is not
greener than your neighbors. Right? So the worry. So what we found is when
you actually increase the control of fear and you actually feel more
relaxed, then your anxiety is reduced and sleep getting better.
So that is what is happening right now. Actually, when we're doing, what I
call, [inaudible 00:02:58] because we even [inaudible 00:03:00] and a lot
of our friends, obviously, take it and that's actually instead of feel the
significant enhance of memory because you cannot... when your memory is
getting better, it's hard to quantify.
Dr. Liu: But when you actually get a better sleep and you feel calm, it's
easy to say, "Oh, wait a minute. I feel... yesterday I sleep five hours.
Now I sleep six hours and I feel calm today and I don't feel panic." Their
interview is supposed to be 8:00 sharp and at 8:29 I am still walking
around. Could not find the home, this house, room, but I'm not panicked.
Dr. Liu: So that is actually something we observe when we actually increase
the brain magnesium. But [magnesically], is we increase the number of
synapse in the brain region which come through the fear is everything is
under control, that your not panicked, that you don't feel stress. If you
don't feel stress, you get a better sleep. When you get a better sleep,
your memory function even better the day after. So that's how we believe
from [inaudible 00:04:08] point of view, from biology point of view why
[inaudible 00:04:13] brain magnesium can help you. So this is not about
Alzheimer's disease, this just more about magnesium supplement for people
feel daily stress.
Dr. Guosong Liu illustrates how magnesium can help your stress response and, in turn, your sleep. Dr. Liu discusses how this revelation came about while studying magnesium's affect on memory, and in particular fear memory. Find out how they are all tied together.
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