Interviewer: Doctor, somebody takes Magtein. What can they expect to see
in terms of differences, and how long might that be before they start
noticing results? So what kind of results and how long?
Professor Liu: Of course, whatever I say here, I have to be cautious to
other people. We have here four double-blind, placebo-controlled human
experiments undergoing. Right now, whatever I talk is about 100 people we
give what I call [open label]. So that is a double-blind experiment
control. That's just like a standard medical trial.
Before that we have this what I call [open label], just give it to their
friends and they know they are taking [magnesium]. Normally, we should do
the experiment, [give you] I say, "This is a great compound," but in fact I
gave you some starch. You might say, "Oh, yeah. I'm taking [Magtein]. I
should be smarter tomorrow." So, I'm supposed to do that, but our internal
experiment we're just giving it to the people without... We tell you,
"Okay. Here's [Magtein]. (inaudible 00:01:05)."
So in our original (inaudible 00:01:07) remember we were designing a memory
enhancer. In animals an experiment takes three weeks to see improvement of
Professor Liu: Okay, so we originally think this (inaudible 00:01:18) is
going to take three weeks to one month to see any facts. What we are a
little bit surprised at right now is the people report to us and say, "Hey,
wait a minute. You told us we should have one month (inaudible 00:01:29)
and now we feel something much, much earlier like (inaudible 00:01:32) in
one week." So what's happening is this gets into the sleep study.
So for most people when they take this form of [magnesium], first they
notice the first night or first week, they get a much better sleep. Okay.
The sleep is much better, so that's what they report to us. We aren't even
worried about a placebo, of course, as a science. We're worried about - we
think, "Oh, they believe me. They believe, 'Okay, that doctor, he was so
cool and his studies were fascinating and this (inaudible 00:02:03) work'."
They might really have some effects, but sometimes I feel it's harder to
fake sleep. Right? So if you sleep five hours, and no matter how much you
like my research, you can't get six hours. Right? So right now, most
people, about 70% of people get improvement of sleep in the first few days.
They sleep deeper and when they wake up they feel more energetic.
Now, my latest understanding about this problem is I know if I can help
other people sleep, their performance will be better. That part I'm
confident. It's just, (inaudible 00:02:45) experience when you have a
better sleep and you feel the sky is blue, energetic, and you can solve
problems. You feel confident.
So, the first science improved on the sleep and now we found that in terms
of subjective feeling, remember memory is a function. If I don't use some
kind of memory task on you, you don't know because you don't need that much
memory. Right? So you don't even know your memory is getting better unless
you really have a very poor memory. You're parking your car and you don't
know where it is every day.
Okay? But even there you have help. You can say, "I'm going to write down
the location." Right? So you can solve that problem either way, which means
if I do increase your memory it's hard for you to know. You might say, "Is
this really working?" You don't know, but you (inaudible 00:03:37) sleep
whether you wake up, how many times you wake up in the middle of the night.
That is something we notice there is a difference on that. There's less
waking up in the evening.
Also, the sleep is deeper. Also, the day after, the people told us they are
more calm, tranquility, and [it's not easily lost.] For me, it's less
likely to lose my temper at 6:00 in the evening. Like, I've been working
for 12 hours. My student asks me, "Oh my God. Oh, don't give me (inaudible
00:04:14)," right? So I actually feel much calmer at 6:00.
But my (inaudible 00:04:21) I actually have very high magnesium, so
normally I'm not supposed to take this. But I take this if I anticipate a
long working day. What (inaudible 00:04:29) is the end of the working day
I'm still functioning (inaudible 00:04:34). So, if you don't see any
effects in one month, then this doesn't help you.
Professor Liu: To help you, this should be about one month. We say one
month. So now we feel actually for people who have a sleep problem, this
will help to sleep deeper. But unlike the sleeping pill, this helps you
sleep in a physiologic way. The day after there are no side effects of
taking sleeping pills. This will make you feel more energetic because this
promotes the natural sleep.